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| Nomenclature |
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Symbol:
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Gab1tm1Ajw
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Name:
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growth factor receptor bound protein 2-associated protein 1;
targeted mutation 1, Albert J Wong
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MGI ID: |
MGI:2667211 |
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Synonyms: |
Gab1- |
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Gene:
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Gab1
Location:
Chr8:80764434-80880479 bp, - strand
Genetic Position: Chr8,
38.47 cM, cytoband C3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83953
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exon 2, which contains part of the PH domain, was replaced with a neomycin resistance gene. Homologous recombination was confirmed in heterozygous mice and homozygous embryos by PCR and by Western blots. (J:83953)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gab1 Mutation:
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39 strains or lines available |
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| References |
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Original: |
J:83953
Holgado-Madruga M et al.,
"Gab1 is an integrator of cell death versus cell survival signals in oxidative stress."
Mol Cell Biol 2003 Jul;23(13):4471-84
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All: |
1 reference(s)
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Analysis Tools
