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| Nomenclature |
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Symbol:
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Fras1tm1Chpk
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Name:
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Fraser syndrome 1 homolog (human);
targeted mutation 1, George Chalepakis
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MGI ID: |
MGI:2667194 |
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Synonyms: |
Fras1- |
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Gene:
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Fras1
Location:
Chr5:96373955-96784728 bp, + strand
Genetic Position: Chr5,
47.29 cM
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Defective septation of right lung lobes in Fras1tm1Chpk/Fras1tm1Chpk embryos
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83746
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: A lacZ/neo cassette was inserted into exon 6 of the gene. Immunofluorescence staining failed to detect protein in homozygous mutant mice. (J:83746)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:83746
Vrontou S et al.,
"Fras1 deficiency results in cryptophthalmos, renal agenesis and blebbed phenotype in mice."
Nat Genet 2003 Jun;34(2):209-14
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All: |
4 reference(s)
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Analysis Tools
