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| Nomenclature |
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Symbol:
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Gucy2ctm1Gar
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Name:
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guanylate cyclase 2c;
targeted mutation 1, David L Garbers
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MGI ID: |
MGI:2665316 |
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Synonyms: |
Gcc-, GC-C - |
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Gene:
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Gucy2c
Location:
Chr6:136697285-136781765 bp, - strand
Genetic Position: Chr6,
66.67 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:43046
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Parent Cell Line:
| SM1 (ES Cell) |
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Strain of Origin:
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129S6/SvEvTac
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: Exon 1 was disrupted by a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of intestinal mucosal scrapings obtained from homozygous mutant mice. Total intestine mucosal guanylyl cyclase activity was reduced 16-fold relative to wild-type controls, whereas heat-stable enterotoxin (STa)-stimulable guanylyl cyclase activity was absent in mutant mice. (J:43046)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:43046
Schulz S et al.,
"Disruption of the guanylyl cyclase-C gene leads to a paradoxical phenotype of viable but heat-stable enterotoxin-resistant mice."
J Clin Invest 1997 Sep 15;100(6):1590-5
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All: |
8 reference(s)
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Analysis Tools
