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| Nomenclature |
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Symbol:
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Tg(Igh-Abl1)40Sco
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Name:
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transgene insertion 40, Suzanne Cory
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MGI ID: |
MGI:2665029 |
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Synonyms: |
EmuSV-v-abl, Emu-v-abl |
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Transgene:
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Tg(Igh-Abl1)40Sco
Location:
unknown
Genetic Position: Chr14,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6JWehi X SJL/JWehi)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene used the mouse Igh enhancer and the SV40 early promoter region to drive a gag-Abl1 fusion sequence in lymphoid cells. The transgene is expressed in hematopoietic tissues and in all tumors. (J:78204)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Notes |
Four transgenic lines were created. Line v-abl 1 harbors more than 1 transgene and exhibits only lymphomas (will be described elswhere). Lines v-abl 40, v-abl 8, and v-abl 2 develop plasmocytomas.
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| References |
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Original: |
J:78204
Rosenbaum H et al.,
"An E mu-v-abl transgene elicits plasmacytomas in concert with an activated myc gene."
EMBO J 1990 Mar;9(3):897-905
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All: |
5 reference(s)
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Analysis Tools
