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| Nomenclature |
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Symbol:
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Keratm1Cyl
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Name:
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keratocan;
targeted mutation 1, Chia-Yang Liu
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MGI ID: |
MGI:2664936 |
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Synonyms: |
Kera- |
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Gene:
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Kera
Location:
Chr10:97607205-97613688 bp, + strand
Genetic Position: Chr10,
50.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83873
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: About 1 kb of intron 1 and all but the last 0.6kb of exon 2 were replaced with a neomycin-resistance gene inserted in antisense orientation. In-situ hybridization indicated no mRNA in the cornea of homozygous mutant mice and protein was undetectable by immunohistochemical staining or by Western blot analysis. (J:83873)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Kera Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:83873
Liu CY et al.,
"Keratocan-deficient mice display alterations in corneal structure."
J Biol Chem 2003 Jun 13;278(24):21672-7
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All: |
5 reference(s)
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Analysis Tools
