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| Nomenclature |
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Symbol:
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Men1tm1Zqw
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Name:
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multiple endocrine neoplasia 1;
targeted mutation 1, Zhao-Qi Wang
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MGI ID: |
MGI:2664869 |
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Synonyms: |
Men1T |
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Gene:
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Men1
Location:
Chr19:6334979-6340891 bp, + strand
Genetic Position: Chr19,
4.45 cM, cytoband A
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83882
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: A cassette expressing the neomycin resistance gene and the thymidine kinase gene flanked by loxP sites was inserted into intron 2. An additional loxP site was placed in intron 3. Homologous recombination was confirmed by Southern blots. The insertion of a neoTK cassette into intron 2 of the Men1 locus (the T allele) disrupted the Men1 expression at RNA and protein levels, as shown by RT-PCR and Western blot, respectively. (J:83882)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:83882
Bertolino P et al.,
"Genetic ablation of the tumor suppressor menin causes lethality at mid-gestation with defects in multiple organs."
Mech Dev 2003 May;120(5):549-60
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All: |
5 reference(s)
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Analysis Tools
