Tg(DO11.10)10Dlo
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(DO11.10)10Dlo
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Name:
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transgene insertion 10, Dennis Y Loh
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MGI ID: |
MGI:2664398 |
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Synonyms: |
CO11.10 TCR-alphabeta, DO.10 Tg, DO11, DO.11, DO-11.10, DO11.10, Do11.10 alphabetaTCR, Do11.10 alphabeta TCR, DO11.10 alphabeta-TCR, DO.11.10 TCR, DO11.10 TCR, DO11.10TCRalphabeta, DO11.10 TCR Tg, DO11 TCR, DO-Tg, OVA-TCRtg, Tg(DO11.10)Tcra/Tcrb, TgN(DO11.10)10Dlo, TgN(DO11.10)10Loh |
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Transgene:
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Tg(DO11.10)10Dlo
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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Not Specified
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains rearranged Tcra and Tcrb genes and is expressed in the majority of T cells. These rearranged transgenes encode a chicken ovalbumin-specific MHC class II (I-Ad)-restricted T cell receptor. (J:25536, J:61321)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Mice carrying this MHC class II restricted rearranged T cell receptor transgene on a H2d background react to ovalbumin (OVA) peptide antigen. Intraperitoneal administration of OVA to transgenic mice results in a rapid deletion of the immature CD4+ CD8+ TCRlo thymocytes with progression to mature thymocytes. Apoptosis of cortical thymocytes in these mice occurs within 20 hours of treatment.
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| References |
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Original: |
J:70572
Murphy KM et al.,
"Induction by antigen of intrathymic apoptosis of CD4+CD8+TCRlo thymocytes in vivo."
Science 1990 Dec 21;250(4988):1720-3
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All: |
554 reference(s)
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Analysis Tools
