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| Nomenclature |
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Symbol:
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Prkcqtm1Litt
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Name:
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protein kinase C, theta;
targeted mutation 1, Dan Littman
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MGI ID: |
MGI:2664379 |
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Synonyms: |
PKCtheta-, PKC-Theta- |
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Gene:
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Prkcq
Location:
Chr2:11172113-11301226 bp, + strand
Genetic Position: Chr2,
8.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83922
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The exon encoding the ATP-binding site of the kinase domain (aa 396 - 451) was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in thymocytes or T cells obtained from mutant mice. (J:83922)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:83922
Sun Z et al.,
"PKC-theta is required for TCR-induced NF-kappaB activation in mature but not immature T lymphocytes."
Nature 2000 Mar 23;404(6776):402-7
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All: |
62 reference(s)
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Analysis Tools
