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| Nomenclature |
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Symbol:
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Epas1tm1Pec
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Name:
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endothelial PAS domain protein 1;
targeted mutation 1, Peter Carmeliet
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MGI ID: |
MGI:2663583 |
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Synonyms: |
Hif2alpha- |
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Gene:
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Epas1
Location:
Chr17:86753907-86833410 bp, + strand
Genetic Position: Chr17,
56.9 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:83549
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 2 with a neomycin resistance cassette via homologous recombination. Exon 2 encodes the basic helix-loop-helix domain which is essential for DNA binding and dimerization. (J:83549)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Epas1 Mutation:
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21 strains or lines available |
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| References |
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Original: |
J:83549
Brusselmans K et al.,
"Heterozygous deficiency of hypoxia-inducible factor-2alpha protects mice against pulmonary hypertension and right ventricular dysfunction during prolonged hypoxia."
J Clin Invest 2003 May;111(10):1519-27
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All: |
8 reference(s)
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Analysis Tools
