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| Nomenclature |
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Symbol:
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Gpc3tm1Arge
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Name:
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glypican 3;
targeted mutation 1, Argiris Efstratiadis
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MGI ID: |
MGI:2657134 |
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Synonyms: |
Gpc3-, Gpc3deltaex1 |
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Gene:
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Gpc3
Location:
ChrX:52272426-52613950 bp, - strand
Genetic Position: ChrX,
28.74 cM, cytoband A3.3
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:75054
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: Sequence encompassing a portion of the putative promoter region and all of exon 1 was replaced with a neomycin selection cassette inserted by homologous recombination. Transcript was undetected by Northern blot analysis of homozygous mutant embryos at E12.5. (J:75054)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Gpc3 Mutation:
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16 strains or lines available |
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| References |
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Original: |
J:75054
Chiao E et al.,
"Overgrowth of a mouse model of the Simpson-Golabi-Behmel syndrome is independent of IGF signaling."
Dev Biol 2002 Mar 1;243(1):185-206
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All: |
1 reference(s)
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Analysis Tools
