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| Nomenclature |
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Symbol:
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Loxtm1Ikh
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Name:
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lysyl oxidase;
targeted mutation 1, Ian K Hornstra
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MGI ID: |
MGI:2657016 |
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Synonyms: |
LOX- |
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Gene:
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Lox
Location:
Chr18:52517238-52529708 bp, - strand
Genetic Position: Chr18,
28.22 cM
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Thoracic aorta abnormalities in Loxtm1Ikh/Loxtm1Ikh mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82926
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Parent Cell Line:
| RW-4 (ES Cell) |
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Strain of Origin:
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129X1/SvJ
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette into exon 1 via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis. (J:82926)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lox Mutation:
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1 strain or line available |
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| References |
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Original: |
J:82926
Hornstra IK et al.,
"Lysyl oxidase is required for vascular and diaphragmatic development in mice."
J Biol Chem 2003 Apr 18;278(16):14387-93
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All: |
1 reference(s)
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Analysis Tools
