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| Nomenclature |
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Symbol:
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Kif5atm1Gsn
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Name:
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kinesin family member 5A;
targeted mutation 1, Lawrence S B Goldstein
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MGI ID: |
MGI:2656900 |
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Synonyms: |
KIF5Anull, Kinesin-1A- |
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Gene:
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Kif5a
Location:
Chr10:127225696-127263363 bp, - strand
Genetic Position: Chr10,
74.5 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82911
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Two coding exons were flanked with a floxed PGK-neo cassette and single loxP site via homologous recombination. The 2 exons and PGK-neo cassette were removed by transient expression of cre recombinase in correctly targeted ES cells. Western blot analysis of brain extracts from homozygous mutant embryos confirmed the absence of gene expression. (J:82911)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:82911
Xia CH et al.,
"Abnormal neurofilament transport caused by targeted disruption of neuronal kinesin heavy chain KIF5A."
J Cell Biol 2003 Apr 14;161(1):55-66
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All: |
2 reference(s)
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Analysis Tools
