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| Nomenclature |
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Symbol:
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Tg(Sox2-cre)1Amc
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Name:
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transgene insertion 1, Andrew P McMahon
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MGI ID: |
MGI:2656539 |
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Synonyms: |
Sox2-cre, Sox2Cre, Sox2::Cre |
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Transgene:
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Tg(Sox2-cre)1Amc
Location:
unknown
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Focal dermal hypoplasia-like phenotypes in Porcntm1.1Lcm/Porcn+ Tg(Sox2-cre)1Amc/0 embryos
Show the 10 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x CBA)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: This transgene expresses Cre recombinase under the control of a mouse Sox2 promoter. Expression of this transgene is sex-dependent, with increased efficiency when passed through the female germline. When the transgene is passed through the male germline, cre activity is observed in epiblast cells as early as E6.5 of only those embryos that inherit the transgene and no expression is detected in extraembryonic tissue. When the transgene is passed through the female germline, cre activity is observed throughout the embryo (including the yolk sac) in all early embryos regardless of whether or not they inherit the transgene. (J:83040, J:86588, J:124941, J:134483, J:178271)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:83040
Hayashi S et al.,
"Efficient gene modulation in mouse epiblast using a Sox2Cre transgenic mouse strain."
Mech Dev 2002 Dec;119 Suppl 1():S97-S101
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All: |
138 reference(s)
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Analysis Tools
