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| Nomenclature |
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Symbol:
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Tsc1tm1Djk
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Name:
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tuberous sclerosis 1;
targeted mutation 1, David J Kwiatkowski
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MGI ID: |
MGI:2656240 |
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Synonyms: |
Tsc1c, Tsc1fl, Tsc1flox, Tsc1L, Tsc1lox |
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Gene:
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Tsc1
Location:
Chr2:28641228-28691167 bp, + strand
Genetic Position: Chr2,
19.38 cM, cytoband B-C1.1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82532
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A floxed neo-TK cassette was inserted into the intron preceding exon 17 and a third loxP site was introduced downstream of exon 18 by homologous recombination. (J:75243)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:82532
Uhlmann EJ et al.,
"Astrocyte-specific TSC1 conditional knockout mice exhibit abnormal neuronal organization and seizures."
Ann Neurol 2002 Sep;52(3):285-96
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All: |
64 reference(s)
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Analysis Tools
