|
|
| Nomenclature |
|
Symbol:
|
Casp8tm1Raz
|
|
Name:
|
caspase 8;
targeted mutation 1, Razqallah Hakem
|
|
MGI ID: |
MGI:2655730 |
|
Synonyms: |
Casp8fl, casp8fl4-3 |
|
Gene:
|
Casp8
Location:
Chr1:58795374-58847503 bp, + strand
Genetic Position: Chr1,
29.19 cM, cytoband B
|
|
Mutation
origin |
|
Germline Transmission:
|
Earliest citation of germline transmission:
J:82759
|
|
Parent Cell Line:
| E14K (ES Cell) |
|
Strain of Origin:
|
129P2/OlaHsd
|
|
Mutation
description |
|
Allele
Type: | |
Targeted (Floxed/Frt) |
|
Mutation: | |
Insertion |
| |
|
Mutation details: A loxP site was inserted upstream of exon 3 and a floxed neo-tk cassette was inserted downstream of exon 4. The neo-tk cassette was removed by transient expression of cre recombinase in correctly targeted ES cells. Resulting mutant animals carry loxP-flanked exons 3-4. (J:82759)
|
|
Phenotypes
|
View phenotypes for all genotypes (concatenated display).
|
|
Disease models
|
|
| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
|
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
|
Carrying any Casp8 Mutation:
|
4 strains or lines available |
|
| References |
|
Original: |
J:82759
Salmena L et al.,
"Essential role for caspase 8 in T-cell homeostasis and T-cell-mediated immunity."
Genes Dev 2003 Apr 1;17(7):883-95
|
|
All: |
11 reference(s)
|
|
Analysis Tools
