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| Nomenclature |
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Symbol:
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Tbx3tm1Pa
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Name:
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T-box 3;
targeted mutation 1, Virginia Papaioannou
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MGI ID: |
MGI:2655214 |
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Gene:
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Tbx3
Location:
Chr5:119670862-119684724 bp, + strand
Genetic Position: Chr5,
60.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82458
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3.2 kb genomic fragment encompassing 3 exons was replaced with a floxed selection cassette that was subsequently removed in vitro via cre mediated excision. A single loxP site was left in place of exons 2, 2a, and 3, which encoded 158 residues of the T domain. (J:82458)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tbx3 Mutation:
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15 strains or lines available |
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| References |
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Original: |
J:82458
Davenport TG et al.,
"Mammary gland, limb and yolk sac defects in mice lacking Tbx3, the gene mutated in human ulnar mammary syndrome."
Development 2003 May;130(10):2263-73
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All: |
6 reference(s)
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Analysis Tools
