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| Nomenclature |
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Symbol:
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Six1tm1Mair
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Name:
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sine oculis-related homeobox 1;
targeted mutation 1, Pascal Maire
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MGI ID: |
MGI:2655195 |
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Synonyms: |
Six1-, Six1lacZ |
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Gene:
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Six1
Location:
Chr12:73041827-73046712 bp, - strand
Genetic Position: Chr12,
30.34 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82459
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Parent Cell Line:
| MPI-II (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The N-terminal portion of the gene was deleted by replacement of exon 1 with a lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunohistochemical analysis. (J:82459)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Six1 Mutation:
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6 strains or lines available |
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Notes |
These ES cells were additionally targeted in J:98519 to create Six1Six4 double knockouts.
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| References |
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Original: |
J:82459
Laclef C et al.,
"Altered myogenesis in Six1-deficient mice."
Development 2003 May;130(10):2239-52
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All: |
24 reference(s)
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Analysis Tools
