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| Nomenclature |
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Symbol:
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Tlx2tm1Sjk
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Name:
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T cell leukemia, homeobox 2;
targeted mutation 1, Stanley J Korsmeyer
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MGI ID: |
MGI:2655186 |
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Synonyms: |
Enx-, Hox11L1- |
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Gene:
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Tlx2
Location:
Chr6:83068317-83070293 bp, - strand
Genetic Position: Chr6,
35.94 cM, cytoband C3-D1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40722
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Parent Cell Line:
| Other (see notes) (ES Cell) |
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Strain of Origin:
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129
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 5' portion of exon 1, including the start codon, was replaced with a neomycin selection cassette inserted by homologous recombination. (J:40722)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tlx2 Mutation:
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2 strains or lines available |
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Notes |
ES cell line = RW-4 (129X1/SvJ) or GS1 (129/Sv); see J:40722.
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| References |
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Original: |
J:40722
Shirasawa S et al.,
"Enx (Hox11L1)-deficient mice develop myenteric neuronal hyperplasia and megacolon."
Nat Med 1997 Jun;3(6):646-50
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All: |
2 reference(s)
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Analysis Tools
