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| Nomenclature |
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Symbol:
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Tbx19tm1Jdr
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Name:
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T-box 19;
targeted mutation 1, Jacques Drouin
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MGI ID: |
MGI:2655153 |
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Synonyms: |
Tpit- |
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Gene:
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Tbx19
Location:
Chr1:165137855-165160773 bp, - strand
Genetic Position: Chr1,
72.47 cM, cytoband H2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82562
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encompassing a portion of exon 2 and all of exons 3 through 6 was replaced with a vector containing lacZ and neo. The deleted sequence encoded the majority of the T-box. Normal protein was undetected in homozygous mutant mice by immunohistochemical analysis. The lacZ expression pattern was similar to that of the endogenous gene. (J:82562)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tbx19 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:82562
Pulichino AM et al.,
"Tpit determines alternate fates during pituitary cell differentiation."
Genes Dev 2003 Mar 15;17(6):738-47
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All: |
5 reference(s)
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Analysis Tools
