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| Nomenclature |
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Symbol:
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Bcl2l1tm1Tak
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Name:
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BCL2-like 1;
targeted mutation 1, Junji Takeda
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MGI ID: |
MGI:2654939 |
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Synonyms: |
Bcl-xflox |
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Gene:
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Bcl2l1
Location:
Chr2:152780668-152831728 bp, - strand
Genetic Position: Chr2,
75.41 cM, cytoband H1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82661
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (Floxed/Frt) |
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Mutation: | |
Insertion |
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Mutation details: A loxP site was introduced upstream of exon 1 and a floxed neo cassette was inserted downstream of exon 2 via homologous recombination. The floxed neo cassette was subsequently removed by mating mutant animals to cre deleter strain TgN(EIIa-cre)C5379Lmgd, resulting in animals carrying floxed exon 1-2 alleles. (J:82661)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:82661
Umeda J et al.,
"In vivo cooperation between Bcl-xL and the phosphoinositide 3-kinase-Akt signaling pathway for the protection of epidermal keratinocytes from apoptosis."
FASEB J 2003 Apr;17(6):610-20
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All: |
1 reference(s)
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Analysis Tools
