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| Nomenclature |
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Symbol:
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Mybpc3tm1Jse
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Name:
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myosin binding protein C, cardiac;
targeted mutation 1, Jonathan G Seidman
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MGI ID: |
MGI:2654419 |
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Synonyms: |
MyBP-C(Neo), MyBP-Ct |
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Gene:
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Mybpc3
Location:
Chr2:91118144-91136516 bp, + strand
Genetic Position: Chr2,
50.44 cM, cytoband E1
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:58295
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a floxed PGK-neo cassette into exon 30 via homologous recombination. The mutant allele produces a protein that contains 166 novel residues and is 30 amino acids shorter than the wild-type protein. (J:58295)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Mybpc3 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:58295
McConnell BK et al.,
"Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice [published erratum appears in J Clin Invest 1999 Dec;104(12):1771]"
J Clin Invest 1999 Nov;104(9):1235-44
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All: |
2 reference(s)
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Analysis Tools
