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| Nomenclature |
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Symbol:
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MafOfl
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Name:
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avian musculoaponeurotic fibrosarcoma (v-maf) AS42 oncogene homolog;
opaque flecks in lens
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MGI ID: |
MGI:2654153 |
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Synonyms: |
J-361 |
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Gene:
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Maf
Location:
Chr8:115682942-115707794 bp, - strand
Genetic Position: Chr8,
62.61 cM
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Mutation
origin |
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Strain of Origin:
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(C3H/HeEl x 102/El)F1
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Mutation
description |
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Allele
Type: | |
Radiation induced |
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Mutation: | |
Single point mutation |
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Mutation details: The mutation in this mouse was identified as a G to A transition resulting in the amino acid substitution R291Q in the basic region of the DNA binding domain. (J:82475)
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Inheritance: | |
Semidominant |
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:82475
Lyon MF et al.,
"A dominant mutation within the DNA-binding domain of the bZIP transcription factor Maf causes murine cataract and results in selective alteration in DNA binding."
Hum Mol Genet 2003 Mar 15;12(6):585-94
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All: |
1 reference(s)
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Analysis Tools
