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| Nomenclature |
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Symbol:
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Ppp1r3atm1Ptwc
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Name:
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protein phosphatase 1, regulatory (inhibitor) subunit 3A;
targeted mutation 1, Patricia T W Cohen
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MGI ID: |
MGI:2653915 |
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Synonyms: |
Gm |
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Gene:
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Ppp1r3a
Location:
Chr6:14713822-14755274 bp, - strand
Genetic Position: Chr6,
6.31 cM, cytoband A2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82422
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Disruption caused by insertion of vector |
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Mutation details: A single loxP site was left in place of exon 1 after the insertion and subsequent removal of a floxed neo cassette by homologous recombination and in vitro cre mediated excision. The deleted region encoded the start codon as well as the PP1 and glycogen-binding domains. Western blot analysis of homozygous mutant skeletal muscle indicated an absence of protein. (J:82422)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ppp1r3a Mutation:
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1 strain or line available |
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| References |
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Original: |
J:82422
Delibegovic M et al.,
"Disruption of the striated muscle glycogen targeting subunit PPP1R3A of protein phosphatase 1 leads to increased weight gain, fat deposition, and development of insulin resistance."
Diabetes 2003 Mar;52(3):596-604
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All: |
2 reference(s)
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Analysis Tools
