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| Nomenclature |
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Symbol:
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Cd59btm1Jha
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Name:
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CD59b antigen;
targeted mutation 1, Jose A Halperin
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MGI ID: |
MGI:2653298 |
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Synonyms: |
mCd59-, mCd59b- |
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Gene:
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Cd59b
Location:
Chr2:104069849-104091187 bp, + strand
Genetic Position: Chr2,
54.51 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82330
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 3 with a neomycin resistance cassette via homologous recombination. The targeted allele was confirmed by Northern blot and RT-PCR analysis of testes RNA from homozygous mutants. (J:82330)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cd59b Mutation:
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4 strains or lines available |
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Notes |
Embryonic stem cells used were derived from 129/Sv mice.
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| References |
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Original: |
J:82330
Qin X et al.,
"Deficiency of the mouse complement regulatory protein mCd59b results in spontaneous hemolytic anemia with platelet activation and progressive male infertility."
Immunity 2003 Feb;18(2):217-27
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All: |
4 reference(s)
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Analysis Tools
