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| Nomenclature |
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Symbol:
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Leprtm1Mgmj
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Name:
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leptin receptor;
targeted mutation 1, Martin G Myers, Jr
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MGI ID: |
MGI:2653294 |
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Synonyms: |
leprs, leprS1138, s |
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Gene:
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Lepr
Location:
Chr4:101717404-101815352 bp, + strand
Genetic Position: Chr4,
46.96 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82334
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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129/Sv
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Nucleotide substitutions |
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Mutation details: Tyrosine 1138 of exon 18b was replaced with a serine residue (Y1138S) and a neomycin resistance cassette was inserted into the downstream intron via homologous recombination. The Y1138S amino acid substitution specifically disrupts the leptin receptor long form (LRb)-STAT3 signal. Expression of the knock-in allele in mutant animals was confirmed by semi-quantitative RT-PCR analysis of hypothalamus RNA. (J:82334)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:82334
Bates SH et al.,
"STAT3 signalling is required for leptin regulation of energy balance but not reproduction."
Nature 2003 Feb 20;421(6925):856-9
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All: |
16 reference(s)
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Analysis Tools
