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| Nomenclature |
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Symbol:
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Dspptm1Kul
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Name:
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dentin sialophosphoprotein;
targeted mutation 1, Ashok B Kulkarni
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MGI ID: |
MGI:2653208 |
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Synonyms: |
Dspp- |
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Gene:
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Dspp
Location:
Chr5:104170712-104180127 bp, + strand
Genetic Position: Chr5,
50.59 cM
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Tooth abnormalities in Dspptm1Kul/Dspptm1Kul mice
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:84378
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Exons 2 to 5 which span the entire coding region were replaced by a lacZ gene followed by a neomycin resistance gene. Lack of gene expression was established by RT-PCR and in situ hybridization. (J:84378)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:84378
Sreenath T et al.,
"Dentin sialophosphoprotein knockout mouse teeth display widened predentin zone and develop defective dentin mineralization similar to human dentinogenesis imperfecta type III."
J Biol Chem 2003 Jul 4;278(27):24874-80
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All: |
5 reference(s)
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Analysis Tools
