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| Nomenclature |
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Symbol:
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Tlr3tm1Flv
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Name:
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toll-like receptor 3;
targeted mutation 1, Richard A Flavell
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MGI ID: |
MGI:2653138 |
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Synonyms: |
TLR-, Tlr3-, TLR3 |
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Gene:
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Tlr3
Location:
Chr8:45395665-45410539 bp, - strand
Genetic Position: Chr8,
25.31 cM, cytoband B2
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72167
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 1 with a floxed neo cassette via homologous recombination. Northern blot analysis detected a truncated transcript in mutant animals. The mutant transcript does not encode a functional protein. (J:72167)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:72167
Alexopoulou L et al.,
"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3."
Nature 2001 Oct 18;413(6857):732-8
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All: |
104 reference(s)
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Analysis Tools
