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| Nomenclature |
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Symbol:
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Ndntm1.1Mus
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Name:
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necdin;
targeted mutation 1.1, Francoise Muscatelli
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MGI ID: |
MGI:2653064 |
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Gene:
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Ndn
Location:
Chr7:62348277-62349928 bp, + strand
Genetic Position: Chr7,
34.36 cM, cytoband C
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Increased apoptosis in the dorsal root ganglias of Ndntm1.1Mus/Ndn+ mice
Show the 3 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66557
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Parent Cell Line:
| CK35 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Intragenic deletion |
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Mutation details: The 5' two-thirds of the endogenous coding region was replaced with a floxed neo cassette inserted by homologous recombination. The neo cassette was then excised via cre-mediated recombination. (J:66557)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ndn Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:66557
Muscatelli F et al.,
"Disruption of the mouse necdin gene results in hypothalamic and behavioral alterations reminiscent of the human prader-willi syndrome"
Hum Mol Genet 2000 Dec 12;9(20):3101-10
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All: |
7 reference(s)
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Analysis Tools
