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| Nomenclature |
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Symbol:
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Cryab/Hspb2tm1Wawr
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Name:
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crystallin, alpha B;
targeted mutation 1, Eric F Wawrousek
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MGI ID: |
MGI:2652177 |
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Synonyms: |
alphaB-, alphaB/HSPB2-, alphaBKO-168 |
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Gene:
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Cryab
Location:
Chr9:50752758-50756633 bp, + strand
Genetic Position: Chr9,
27.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72926
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intergenic deletion |
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Mutation details: The insertion of a single targeting vector containing neo disrupted both Cryab and Hspb2. All of exons 1 and 2 and a portion of exon 3 were deleted at the Cryab locus. All of exon 1 and a portion of exon 2 were deleted at the Hspb2 locus. Cryab protein was undetected by Western blot analysis of homozgous mutant mice. Northern blot analysis of homozygous mutant heart and skeletal muscle showed an absence of Hspb2 mRNA. (J:72926)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Cryab Mutation:
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2 strains or lines available |
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| References |
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Original: |
J:72926
Brady JP et al.,
"AlphaB-crystallin in lens development and muscle integrity: a gene knockout approach."
Invest Ophthalmol Vis Sci 2001 Nov;42(12):2924-34
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All: |
25 reference(s)
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Analysis Tools
