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| Nomenclature |
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Symbol:
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Ldb3tm1Chen
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Name:
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LIM domain binding 3;
targeted mutation 1, Ju Chen
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MGI ID: |
MGI:2652058 |
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Synonyms: |
cypher- |
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Gene:
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Ldb3
Location:
Chr14:34526699-34588681 bp, - strand
Genetic Position: Chr14,
20.83 cM, cytoband B
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Ventricular dilation in Ldb3tm1Chen/Ldb3tm1Chen hearts
Show the 2 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:72799
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 1 kb fragment containing a portion of both exon 1 and intron 1 was replaced with a lacZ-neo cassette inserted by homologous recombination. No protein was detected by Western blot analysis of homozygous mutant heart tissue. Expression of the beta-galactosidase was driven by the endogenous promoter. (J:72799)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Ldb3 Mutation:
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11 strains or lines available |
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| References |
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Original: |
J:72799
Zhou Q et al.,
"Ablation of Cypher, a PDZ-LIM domain Z-line protein, causes a severe form of congenital myopathy."
J Cell Biol 2001 Nov 12;155(4):605-12
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All: |
1 reference(s)
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Analysis Tools
