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| Nomenclature |
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Symbol:
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Krt17tm1Cou
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Name:
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keratin 17;
targeted mutation 1, Pierre A Coulombe
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MGI ID: |
MGI:2651542 |
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Synonyms: |
K17- |
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Gene:
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Krt17
Location:
Chr11:100256217-100261029 bp, - strand
Genetic Position: Chr11,
63.44 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:82089
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Parent Cell Line:
| CK35 (ES Cell) |
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Strain of Origin:
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129S2/SvPas
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encompassing the proximal promoter, all of exons 1 through 4, and a portion of exon 5 was replaced with a neomycin selection cassette. Northern blot, Western blot, and immunostaining analyses showed an absence of normal transcript and protein in homozygous mutant mice. (J:82089)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Krt17 Mutation:
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6 strains or lines available |
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| References |
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Original: |
J:82089
McGowan KM et al.,
"Keratin 17 null mice exhibit age- and strain-dependent alopecia."
Genes Dev 2002 Jun 1;16(11):1412-22
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All: |
5 reference(s)
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Analysis Tools
