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| Nomenclature |
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Symbol:
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Hba-a1tm1Shs
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Name:
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hemoglobin alpha, adult chain 1;
targeted mutation 1, Takuji Shirasawa
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MGI ID: |
MGI:2451238 |
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Synonyms: |
alphaTitu |
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Gene:
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Hba-a1
Location:
Chr11:32283511-32284465 bp, + strand
Genetic Position: Chr11,
18.86 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:81902
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Parent Cell Line:
| Not Specified (ES Cell) |
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Strain of Origin:
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Not Specified
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutations: | |
Insertion, Single point mutation |
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Mutation details: A transition point mutation was introduced at codon 94 via site directed mutagenesis, resulting in an Asp to Asn substitution at the alpha/beta interface of the hemoglobin molecule. An intronic floxed neo cassette was included downstream of the coding region. (J:81902)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Hba-a1 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:81902
Shirasawa T et al.,
"Oxygen affinity of hemoglobin regulates O2 consumption, metabolism, and physical activity."
J Biol Chem 2003 Feb 14;278(7):5035-43
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All: |
1 reference(s)
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Analysis Tools
