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| Nomenclature |
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Symbol:
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Lipatm1Ggb
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Name:
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lysosomal acid lipase A;
targeted mutation 1, Gregory A Grabowski
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MGI ID: |
MGI:2451080 |
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Synonyms: |
lal- |
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Gene:
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Lipa
Location:
Chr19:34492318-34527474 bp, - strand
Genetic Position: Chr19,
29.7 cM
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Lipid storage in the liver and small intestine and decrease in subcutaneous white adipose tissue in Lipatm1Ggb/Lipatm1Ggb mice as they age
Show the 5 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:49674
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Parent Cell Line:
| E14TG2a (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The gene was disrupted by replacement of exon 5 with an HPRT cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern and Western blot analysis of liver homogenates. (J:49674)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Lipa Mutation:
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1 strain or line available |
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| References |
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Original: |
J:49674
Du H et al.,
"Targeted disruption of the mouse lysosomal acid lipase gene: long-term survival with massive cholesteryl ester and triglyceride storage."
Hum Mol Genet 1998 Sep;7(9):1347-54
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All: |
11 reference(s)
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Analysis Tools
