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| Nomenclature |
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Symbol:
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Itga1tm1Gdnr
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Name:
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integrin alpha 1;
targeted mutation 1, Humphrey Gardner
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MGI ID: |
MGI:2451067 |
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Synonyms: |
alpha1- |
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Gene:
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Itga1
Location:
Chr13:114958079-115101964 bp, - strand
Genetic Position: Chr13,
64.61 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:32930
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a PGK-neo cassette in the reverse orientation into a coding exon via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by immunoprecipitation immunoblot and immunohistochemical analysis. (J:32930)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Itga1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:32930
Gardner H et al.,
"Deletion of integrin alpha 1 by homologous recombination permits normal murine development but gives rise to a specific deficit in cell adhesion."
Dev Biol 1996 May 1;175(2):301-13
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All: |
25 reference(s)
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Analysis Tools
