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| Nomenclature |
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Symbol:
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Six3tm1Gco
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Name:
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sine oculis-related homeobox 3;
targeted mutation 1, Guillermo Oliver
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MGI ID: |
MGI:2450901 |
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Synonyms: |
Six3- |
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Gene:
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Six3
Location:
Chr17:85613608-85631813 bp, + strand
Genetic Position: Chr17,
55.42 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:81797
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutation: | |
Insertion |
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Mutation details: The endogenous allele was disrupted by the in frame insertion of Beta-gal and neo 22 codons downstream of the start codon. An absence of protein in homozygous mutant mice was indicated by immunofluorescence. (J:81797)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Six3 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:81797
Lagutin OV et al.,
"Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development."
Genes Dev 2003 Feb 1;17(3):368-79
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All: |
4 reference(s)
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Analysis Tools
