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| Nomenclature |
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Symbol:
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Tectm1Welm
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Name:
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tec protein tyrosine kinase;
targeted mutation 1, Wilfred Ellmeier
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MGI ID: |
MGI:2450883 |
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Synonyms: |
Tec- |
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Gene:
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Tec
Location:
Chr5:72755718-72868483 bp, - strand
Genetic Position: Chr5,
38.44 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:66080
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Parent Cell Line:
| E14.1 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The insertion of a neomycin selection cassette disrupted the endogenous allele by replacing exon 2 and surrounding intronic sequence. The deleted exon contained the start codon, encoded 45 residues of the Pleckstrin homology domain, and is common to the 4 known isoforms. Western blot analysis showed an absence of full length and truncated protein. (J:66080)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Tec Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:66080
Ellmeier W et al.,
"Severe B cell deficiency in mice lacking the tec kinase family members tec and Btk"
J Exp Med 2000 Dec 4;192(11):1611-24
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All: |
9 reference(s)
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Analysis Tools
