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| Nomenclature |
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Symbol:
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Tg(Plp1-cre/ERT)3Pop
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Name:
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transgene insertion 3, Brian Popko
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MGI ID: |
MGI:2450391 |
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Synonyms: |
PLP/CreER, Plp-CreERt, Plp-Cre-ERT2, Tg(Plp1-cre/ESR1)3.16Pop, Tg(Plp1-cre/ESR1)3Pop, Tg(Plp-cre/ESR1)3.16Pop |
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Transgene:
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Tg(Plp1-cre/ERT)3Pop
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x DBA/2)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct encodes a tamoxifen inducible fusion protein consisting of cre recombinase and a mutated human estrogen receptor ligand binding domain cloned next to a Plp promoter. The 2.5 kb Plp regulatory region includes 5' flanking DNA, exon 1, and intron 1. Transgene expression was confirmed by RT-PCR and Western blot analysis. The mouse Plp promoter was used to drive transgene expression in myelinating cells. (J:81627)
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Recombinase activity
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Activity in:
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alimentary system,
cardiovascular system,
hemolymphoid system,
integumental system,
nervous system,
reproductive system,
respiratory system,
sensory organs
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Not detected in:
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endocrine system,
liver & biliary system,
muscle,
renal & urinary system
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Driver:
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Plp1
Summary of all recombinase alleles
driven by Plp1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:81627
Doerflinger NH et al.,
"Inducible site-specific recombination in myelinating cells."
Genesis 2003 Jan;35(1):63-72
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All: |
16 reference(s)
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Analysis Tools
