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| Nomenclature |
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Symbol:
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Foxk1tm1Djg
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Name:
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forkhead box K1;
targeted mutation 1, Daniel J Garry
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MGI ID: |
MGI:2450307 |
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Synonyms: |
Foxk1-, Mnf- |
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Gene:
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Foxk1
Location:
Chr5:142401497-142462014 bp, + strand
Genetic Position: Chr5,
81.53 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:62225
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: Sequence encoding the winged helix domain was replaced with a neomycin selection cassette by homologous recombination. The targeted sequence is common to both alpha- and beta- isoforms. RT-PCR analysis of homozygous mutant mice indicated an absence of transcript. Protein was undetected by immunohistochemical analysis. (J:62225)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Foxk1 Mutation:
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9 strains or lines available |
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| References |
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Original: |
J:62225
Garry DJ et al.,
"Myogenic stem cell function is impaired in mice lacking the forkhead/winged helix protein MNF."
Proc Natl Acad Sci U S A 2000 May 9;97(10):5416-21
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All: |
2 reference(s)
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Analysis Tools
