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| Nomenclature |
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Symbol:
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Gzmatm1Simn
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Name:
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granzyme A;
targeted mutation 1, Markus M Simon
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MGI ID: |
MGI:2449926 |
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Synonyms: |
GrzA-, gzm A-, gzmA- |
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Gene:
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Gzma
Location:
Chr13:113093827-113100981 bp, - strand
Genetic Position: Chr13,
63.93 cM, cytoband D
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:28773
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Parent Cell Line:
| BL/6-III (ES Cell) |
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Strain of Origin:
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C57BL/6J
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The gene was disrupted by insertion of a neomycin resistance cassette into exon 4 by homologous recombination. Western blot analysis confirmed the absence of protein product and cytochemical analysis demonstrated the absence of enzyme activity in cytotoxic T cells in homozygous mutant animals. (J:28773)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:28773
Ebnet K et al.,
"Granzyme A-deficient mice retain potent cell-mediated cytotoxicity."
EMBO J 1995 Sep 1;14(17):4230-9
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All: |
31 reference(s)
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Analysis Tools
