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| Nomenclature |
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Symbol:
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Slc1a2tm1Kta
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Name:
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solute carrier family 1 (glial high affinity glutamate transporter), member 2;
targeted mutation 1, Kohichi Tanaka
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MGI ID: |
MGI:2449707 |
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Synonyms: |
EAAT2 KO, GLT-1- |
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Gene:
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Slc1a2
Location:
Chr2:102658659-102790784 bp, + strand
Genetic Position: Chr2,
54.13 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:40984
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutation: | |
Insertion |
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Mutation details: The exon encoding the putative third transmembrane domain was disrupted by the insertion of a neomycin selection cassette. While transcript of approximately normal length was detected by Northern blot analysis of homozygous mutant cerebral RNA, RT-PCR analysis showed the transcript to lack exon 4. An absence of normal transcript was confirmed by in situ hybridization. Protein was undetected by Western blot analysis of cerebral membrane fractions. (J:40984)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Slc1a2 Mutation:
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1 strain or line available |
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| References |
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Original: |
J:40984
Tanaka K et al.,
"Epilepsy and exacerbation of brain injury in mice lacking the glutamate transporter GLT-1."
Science 1997 Jun 13;276(5319):1699-702
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All: |
20 reference(s)
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Analysis Tools
