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| Nomenclature |
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Symbol:
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Krit1tm1Dmar
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Name:
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KRIT1, ankyrin repeat containing;
targeted mutation 1, Douglas Marchuk
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MGI ID: |
MGI:2449693 |
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Synonyms: |
Ccm1- |
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Gene:
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Krit1
Location:
Chr5:3803165-3844515 bp, + strand
Genetic Position: Chr5,
2.26 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:88138
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The majority of exon 6 and all of exon 7 was replaced with a lacZ reporter cassette, effectively deleting the first ankyrin repeat of the gene. At E8.5, no expression was detected in homozygous mutant mice by in situ hybridization. (J:88138)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Krit1 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:88138
Whitehead KJ et al.,
"Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations."
Development 2004 Mar;131(6):1437-48
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All: |
5 reference(s)
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Analysis Tools
