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| Nomenclature |
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Symbol:
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Btktm1Gsv
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Name:
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Bruton agammaglobulinemia tyrosine kinase;
targeted mutation 1, Frank Grosveld
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MGI ID: |
MGI:2449487 |
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Synonyms: |
Btk- |
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Gene:
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Btk
Location:
ChrX:134542336-134583570 bp, - strand
Genetic Position: ChrX,
56.18 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:35769
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Parent Cell Line:
| E14 (ES Cell) |
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Strain of Origin:
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129P2/OlaHsd
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A vector was constructed that contained an in-frame fusion of 1.5 kb 5' genomic sequences of the targeted gene (up to exon 8) to the nuclear localization signal (nls) of the SV40 T antigen and the E. coli lacZ gene. After homologous recombination in ES cells, only exons 1 - 7 of the targeted gene were intact and were fused to the lacZ reporter. Western blots of total cell lysates from spleen cells and from thymocytes showed no detectable protein for the targeted gene in hemizygous mutant male mice. (J:35769)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Btk Mutation:
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8 strains or lines available |
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| References |
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Original: |
J:35769
Hendriks RW et al.,
"Inactivation of Btk by insertion of lacZ reveals defects in B cell development only past the pre-B cell stage."
EMBO J 1996 Sep 16;15(18):4862-72
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All: |
17 reference(s)
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Analysis Tools
