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| Nomenclature |
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Symbol:
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Grip1tm1Paw
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Name:
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glutamate receptor interacting protein 1;
targeted mutation 1, Anthony Pawson
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MGI ID: |
MGI:2449094 |
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Synonyms: |
GRIP1- |
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Gene:
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Grip1
Location:
Chr10:119454034-120087261 bp, + strand
Genetic Position: Chr10,
67.33 cM, cytoband D2
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Development of a severe bullous disorder in Grip1tm1Paw/Grip1tm1Paw embryos
Show the 4 image(s) involving this allele.
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:79476
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Parent Cell Line:
| R1 (ES Cell) |
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Strain of Origin:
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(129X1/SvJ x 129S1/Sv)F1-Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (Reporter) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: A 3.6 kb fragment was replaced with a beta-galactosidase gene followed by a floxed neo gene. The deleted region included a 3' portion of the exon encoding the first PDZ domain. No full length protein was detected by Western blot analysis of protein extracts obtained from homozygous mutant embryos. Beta-galactosidase staining indicated that the reporter gene was expressed via the endogenous promoter. (J:79476)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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| References |
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Original: |
J:79476
Bladt F et al.,
"Epidermolysis bullosa and embryonic lethality in mice lacking the multi-PDZ domain protein GRIP1."
Proc Natl Acad Sci U S A 2002 May 14;99(10):6816-21
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All: |
2 reference(s)
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Analysis Tools
