Tg(ACTFLPe)9205Dym
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(ACTFLPe)9205Dym
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Name:
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transgene insertion 9205, Susan Dymecki
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MGI ID: |
MGI:2448985 |
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Synonyms: |
ACTB:FLPe, ACTB::FLPe, ACTFlpe, ACT-FLPe, actin-FLPe, beta-actinFLPe, CAGG-Flpr, CAGGS-flp, Flp, Flp deleter, FLPe, hACTB-FLPe, hACTB::FLPe, TgaFlpe, TgpCAG-flpe |
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Transgene:
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Tg(ACTFLPe)9205Dym
Location:
unknown
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: Sequence encoding FLP1 was adjoined to human ACTB promoter sequence, including 3 kb of promoter sequence and an 0.8 kb portion of exon 1. The promoter region drives expression in the germline. Recombinase activity is detected in a wide variety of tissues (spinal cord, heart, gonad, adrenal) as early as embryonic day 10.5. (J:78660)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
The FLPe recombinase variant exhibits enhanced thermostability with recombination activity being 4X and 10X that of wildtype FLP at 37C and 40C, respectively. Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross p hysical or behavioral abnormalities.
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| References |
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Original: |
J:78660
Rodriguez CI et al.,
"High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP."
Nat Genet 2000 Jun;25(2):139-40
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All: |
459 reference(s)
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Analysis Tools
