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| Nomenclature |
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Symbol:
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Nkx2-5tm2(cre)Rph
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Name:
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NK2 transcription factor related, locus 5 (Drosophila);
targeted mutation 2, Richard P Harvey
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MGI ID: |
MGI:2448972 |
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Synonyms: |
Nkx2.5-Cre, Nkx2-5IRESCre |
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Gene:
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Nkx2-5
Location:
Chr17:26838664-26841565 bp, - strand
Genetic Position: Chr17,
13.6 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:80725
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Parent Cell Line:
| W9.5/W95 (ES Cell) |
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Strain of Origin:
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129S1/Sv-Oca2+ Tyr+ Kitl+
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Mutation
description |
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Allele
Type: | |
Targeted (knock-in) |
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Mutation: | |
Insertion |
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Mutation details: Sequence encoding cre recombinase adjoined to an IRES was inserted into the 3' UTR of the endogenous locus via homologous recombination. A single frt site remained in the UTR after an frt-flanked hygromycin selection cassette was excised. A lack of observed allele complementation indicated that the inserted sequence did not significantly affect expression of the endogenous locus. (J:80725)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nkx2-5 Mutation:
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3 strains or lines available |
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| References |
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Original: |
J:80725
Stanley EG et al.,
"Efficient Cre-mediated deletion in cardiac progenitor cells conferred by a 3'UTR-ires-Cre allele of the homeobox gene Nkx2-5."
Int J Dev Biol 2002;46(4):431-9
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All: |
15 reference(s)
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Analysis Tools
