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| Nomenclature |
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Symbol:
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Tg(tetO-cre)LC1Bjd
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Name:
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transgene insertion LC1, Hermann Bujard
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MGI ID: |
MGI:2448952 |
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Synonyms: |
LC-1, TgLC1, TRE-LC1 |
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Transgene:
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Tg(tetO-cre)LC1Bjd
Location:
unknown
Genetic Position: Chr6,
Syntenic
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x BALB/c)F2
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: The transgenic construct contained a bidirectional tTA/rtTA responsive promoter derived from the human cytomegalovirus promoter IE and flanked by sequence encoding luciferase and cre recombinase. Efficient cre mediated recombination, unaffected by position effect variegation, was demonstrated in hepatocytes. Transcription of in both directions was shown to be activated by rtTA in the presence of doxycycline. Transgene insertion is on chromosome 6C1 flanked by genes coding for the
vomeronasal receptors V1rc14 and V1rc15 (K.Schonig, pers. commun.) (J:81196)
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Recombinase activity
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:81196
Schonig K et al.,
"Stringent doxycycline dependent control of CRE recombinase in vivo."
Nucleic Acids Res 2002 Dec 1;30(23):e134
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All: |
26 reference(s)
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Analysis Tools
