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| Nomenclature |
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Symbol:
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Tg(SOD1)2Gur
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Name:
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transgene insertion 2, Mark E Gurney
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MGI ID: |
MGI:2448770 |
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Synonyms: |
N1029, N29, SOD1WT, tg-SOD1, WTSOD1, WT SOD1 |
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Transgene:
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Tg(SOD1)2Gur
Location:
unknown
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Amyotrophic lateral sclerosis-like lesions in the spinal cord of Tg(SOD1)2Gur/0 and Tg(SOD1-G93A)1Gur/0 mice
Show the 1 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6 x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The transgene contains the normal allele of the human superoxide dismutase 1 gene (SOD1). Transgene expression in brain was confirmed by enzyme immunoassay using antibodies that recognize human SOD1 protein. (J:32665)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Expression level of the wild-type transgene in transgenic animals is comparable to that in transgenic mice carrying the original highest expressing line Tg(SOD1*G93A)2Gur.
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| References |
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Original: |
J:32665
Gurney ME et al.,
"Motor neuron degeneration in mice that express a human Cu,Zn superoxide dismutase mutation [see comments] [published erratum appears in Science 1995 Jul 14;269(5221):149]"
Science 1994 Jun 17;264(5166):1772-5
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All: |
93 reference(s)
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Analysis Tools
