Tg(Vil-cre)997Gum
Transgene Detail
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| Nomenclature |
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Symbol:
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Tg(Vil-cre)997Gum
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Name:
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transgene insertion 997, Deborah L Gumucio
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MGI ID: |
MGI:2448639 |
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Synonyms: |
12.4KbVilCre, Tg(Vil-cre)997Gum, VilCre, Vil-Cre, Villin-cre, Villin.cre, VillinCre |
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Transgene:
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Tg(Vil-cre)997Gum
Location:
unknown
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Show the 5 image(s) involving this allele.
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Transgene
origin |
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Strain of Origin:
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(C57BL/6J x SJL)F1
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Transgene
description |
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Transgene
Type: | |
Transgenic (Cre/Flp) |
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Mutation: | |
Insertion |
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Mutation details: A 12.4-kb promoter fragment from the villin 1 gene drives the expression of cre recombinase. Recombination occurs in villi and crypt cells of the small and large intestines, closely patterning the endogenous gene expression. According to the corresponding author (J:78815), expression is generally continuous but a small amount of mosaicism is noted in the colon. Onset of transgene expression is at 12.5 dpc, which is delayed from the endogenous mouse Vil gene expression onset of 9.0 dpc. (J:78815)
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Recombinase activity
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Activity in:
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alimentary system,
cardiovascular system,
endocrine system,
nervous system,
renal & urinary system,
reproductive system,
respiratory system
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Not detected in:
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adipose tissue,
cavities & their linings,
embryo-other,
extraembryonic component,
hemolymphoid system,
integumental system,
limbs,
liver & biliary system,
mesenchyme,
muscle,
postnatal-other,
sensory organs,
skeletal system,
tail
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Driver:
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Vil1
Summary of all recombinase alleles
driven by Vil1.
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Notes |
Hemizygous transgenic mice are viable, fertile, normal in size, and do not display any gross physical or behavioral abnormalities.
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| References |
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Original: |
J:78815
Madison BB et al.,
"cis Elements of the Villin Gene Control Expression in Restricted Domains of the Vertical (Crypt) and Horizontal (Duodenum, Cecum) Axes of the Intestine."
J Biol Chem 2002 Sep 6;277(36):33275-83
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All: |
132 reference(s)
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Analysis Tools
