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| Nomenclature |
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Symbol:
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Nrg1tm2Zhou
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Name:
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neuregulin 1;
targeted mutation 2, Mingdong Zhou
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MGI ID: |
MGI:2448078 |
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Gene:
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Nrg1
Location:
Chr8:31818028-31918203 bp, - strand
Genetic Position: Chr8,
18.75 cM
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Mutation
origin |
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Germline Transmission:
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Earliest citation of germline transmission:
J:81106
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Parent Cell Line:
| J1 (ES Cell) |
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Strain of Origin:
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129S4/SvJae
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Mutation
description |
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Allele
Type: | |
Targeted (knock-out) |
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Mutations: | |
Insertion, Intragenic deletion |
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Mutation details: The majority of exon 11 and a portion of intron 11 were replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the transmembrane domain. (J:81106)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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Carrying any Nrg1 Mutation:
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5 strains or lines available |
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| References |
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Original: |
J:81106
Stefansson H et al.,
"Neuregulin 1 and susceptibility to schizophrenia."
Am J Hum Genet 2002 Oct;71(4):877-92
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All: |
14 reference(s)
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Analysis Tools
