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| Nomenclature |
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Symbol:
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Tg(Mpz)80.2Wra
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Name:
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transgene insertion 80.2, Lawrence Wrabetz
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MGI ID: |
MGI:2447694 |
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Synonyms: |
Tg80.2 |
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Transgene:
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Tg(Mpz)80.2Wra
Location:
unknown
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Transgene
origin |
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Transgene
description |
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Transgene
Type: | |
Transgenic (random, expressed) |
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Mutation: | |
Insertion |
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Mutation details: The entire Mpz gene (including 6 kb of promoter sequences, all exons and introns, and the natural polyadenylation site) was used as the transgene. Line 80.2 carries over 31 copies of the integrated transgene and overexpression is approximately 7.3-fold that of the endogenous protein. (J:78758)
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Phenotypes
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View phenotypes for all genotypes (concatenated display).
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Disease models
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| Find Mice (IMSR) |
Mouse strains and cell lines available from the
International Mouse Strain Resource
(IMSR)
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Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available |
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| References |
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Original: |
J:78758
Wrabetz L et al.,
"P(0) glycoprotein overexpression causes congenital hypomyelination of peripheral nerves."
J Cell Biol 2000 Mar 6;148(5):1021-34
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All: |
2 reference(s)
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Analysis Tools
